Phenylpropanoids and polyketides
Medchemexpress LLC (-)-Epigallocatechin | 970-74-1 | 99.7% | 306.27 | 25 MG
(-)-Epigallocatechin, a major flavonoid in green tea, prevents amyloid fibril formation by binding to unfolded polypeptides and stabilizing their native-like state. It also exhibits antimicrobial effects, eradicating E. faecalis biofilms and reducing virulence through hydroxyl radical induction.
- Most abundant flavonoid in green tea.
- Binds to unfolded native polypeptides.
- Prevents amyloid fibril conversion.
- Stabilizes native-like molecular states.
- Eradicates E. faecalis biofilms.
- Induces hydroxyl radicals in E. faecalis.
- Down-regulates E. faecalis virulence genes.
Selleck Chemical LLC AST-487
AST-487 (NVP-AST487) a N N -diphenyl urea is an ATP competitive inhibitor of Flt3 with ki of 0 12 M Besides FLT3 AST487 also inhibits RET KDR c-KIT and c-ABL kinase with IC50 values below 1 M
Medchemexpress LLC Chrysin 6-C-glucoside 8-C-arabinoside | 185145-34-0 | 98.6% | 5 MG
Chrysin 6-C-glucoside 8-C-arabinoside is a flavonoid glycoside used in preclinical research. It has been reported to inhibit calcitonin gene-related peptide (CGRP) release and to block activation of the TRPV1 channel, making it useful in studies related to migraine mechanisms and neuropharmacology.
- Flavonoid glycoside that inhibits CGRP release and TRPV1 activation.
- Used in anti-migraine and neuropharmacology research.
- Molecular formula C26H28O13; molecular weight 548.49 g/mol.
- Purity typically around 98.6% as supplied.
- Available in small research packs (5 mg, 10 mg, 50 mg, 100 mg).
- Store protected from light at 4°C; in solution, store at -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Chrysin 6-C-glucoside 8-C-arabinoside | 185145-34-0 | 98.6% | 10 MG
Chrysin 6-C-glucoside 8-C-arabinoside is a flavonoid glycoside used in pharmacological research; it has been reported to inhibit calcitonin gene-related peptide (CGRP) release and to block TRPV1 channel activation, supporting anti-migraine and TRPV1-focused studies.
- Reported inhibitor of CGRP release.
- Blocks TRPV1 channel activation.
- High purity suitable for in vitro pharmacology studies.
- Molecular formula C26H28O13 and molecular weight 548.49 g/mol.
- Available in small-mass packages for assay development.
Medchemexpress LLC HY-17466 5mg Medchemexpress, Sancycline CAS:808-26-4 Purity:>98%
Medchemexpress, HY-17466 5mg Sancycline CAS:808-26-4 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC AST 487 630124-46-8 10mM (in 1mL DMSO)
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Apexbio Technology LLC (±)-AMG 487 50mg
racemic Baclofen -AMG 487 is a small-molecule antagonist targeting the chemokine receptor CXCR3 It is designed to inhibit ligand-induced CXCR3-mediated immune cell migration thereby modulating lymphocyte recruitment to inflammatory and metastatic sites racemic Baclofen -AMG 487 exerts its biological activity primarily through selective inhibition of CXCR3-mediated cell migration In in vitro studies racemic Baclofen -AMG 487 demonstrates inhibition of ligand-induced CXCR3-dependent cell movement Based on these pharmacological properties racemic Baclofen -AMG 487 holds research potential in inflammation and oncology studies
Medchemexpress LLC Apigenin (Standard) | 520-36-5 | 270.24 | 25 MG
Apigenin (Standard) is the analytical standard of Apigenin, intended for research and analytical applications. It is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Reference standard supplied assay
- For research use only
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 2 MG
AMG 487 (S-enantiomer) is the S enantiomer of AMG 487, functioning as an antagonist of the chemokine receptor CXCR3. It is intended for research use only.
- Antagonist of chemokine receptor
- Available in solid and solution forms
- High purity (99.94%)
- Off-white to light yellow appearance
- Stable for extended periods under proper storage conditions
Apexbio Technology LLC Palomid 529 914913-88-5 5mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization